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Här är några studier ni kan titta närmare på så kanske det blir lättare att förstå CCSVI...

Rindfleisch E. - "Histologisches detail zu der grauen degeneration von gehirn und ruckenmark". Archives of Pathological Anatomy and Physiology. 1863;26:474–483.

Charcot JM: Histologie de la sclérose en plaque. Gazette Hosp Paris 41:554-566.

Rindfleisch E: A Manual of Pathological Histology. London, New Sydenham Society, 1872, Vol. 2, pp. 344–351.

Dawson JW: The histology of disseminated sclerosis. Trans Roy Soc Edinb, 50: 517, 1916.

Putnam T: "Encephalitis" and sclerotic plaques produced by venular obstruction. Arch Neurol Psychiatry. 1935;33(5):929-940.

Putnam T and Adler A: Vascular architecture of the lesions of multiple sclerosis. Arch Neurol Psychiat, 38:1, 1937.

Putnam T: Evidences of vascular occlusion in multiple sclerosis and encephalomyelitis. Arch Neurol Psychiatry 1937;37(6):1298-1321.

Schlesinger B: The venous drainage of the brain, with special reference to the galenic system. Brain, 62:274, 1939.

Dow RS, Berglund G: Vascular pattern of lesions of multiple sclerosis. Arch Neurol Psychiatry. 1942;47(1):1-18

Zimmerman HM, and Netsky MG: The pathology of multiple sclerosis. Res Publ Assoc Res Nerv Ment Dis. 1950 ;28:271-312.

Fog T. On the vessel-plaque relations in the brain in multiple sclerosis. Acta Psychiat Neurol Scand. 1963; 39, suppl. 4:258

Fog T: On the Vessel-Plaque Relationships in the Brain in Multiple Sclerosis. Acta Neurol Scand Suppl. 1964 ;40:SUPPL 10:9-15.

Fog T: The topography of plaques in multiple sclerosis with special reference to cerebral plaques. Acta Neurol Scand Suppl. 1965 ;15:1-161.

Walton JC, and Kaufmann JC: Iron deposits and multiple sclerosis. Arch Pathol Lab Med. 1984 Sep;108(9):755-6.


Adams CW: The onset and progression of the lesion in multiple sclerosis. J Neurol Sci. 1975 Jun;25(2):165-82.

Adams CW, Poston RN, Buk SJ, Sidhu YS, and Vipond H: Inflammatory vasculitis in multiple sclerosis. J Neurol Sci. 1985 Jul;69(3):269-83.

Lightman S, McDonald WI, Bird AC, Francis DA, Hoskins A, Batchelor JR, and Halliday AM: Retinal venous sheathing in optic neuritis. Its significance for the pathogenesis of multiple sclerosis. Brain. 1987 Apr;110 (Pt 2):405-14.

Schelling F: Damaging venous reflux into the skull or spine: relevance to multiple sclerosis. Med Hypotheses. 1986 Oct;21(2):141-8.

Adams CW, Abdulla YH, Torres EM, and Poston RN: Periventricular lesions in multiple sclerosis: their perivenous origin and relationship to granular ependymitis. Neuropathol Appl Neurobiol. 1987 Mar-Apr ;13(2):141-52.

Nicolson M, McLaughlin C: Social constructionism and medical sociology: a study of the vascular theory of multiple sclerosis. Sociology of Health & Illness Vol. 10 No. 3, pp. 234–261 1988, published online: 28 Jun 2008

Adams CW: Perivascular iron deposition and other vascular damage in multiple sclerosis. J Neurol Neurosurg Psychiatry. 1988 Feb;51(2):260-5.

Oger J, Kastrukoff LF, Li DK, and Paty DW: Multiple sclerosis: in relapsing patients, immune functions vary with disease activity as assessed by MRI. Neurology. 1988 Nov;38(11):1739-44.

Kermode AG, Thompson AJ, Tofts P, MacManus DG, Kendall BE, Kingsley DP, Moseley IF, Rudge P, and McDonald WI: Breakdown of the blood-brain barrier precedes symptoms and other MRI signs of new lesions in multiple sclerosis. Pathogenetic and clinical implications. Brain. 1990 Oct;113 ( Pt 5):1477-89.

Birch MK, Barbosa S, Blumhardt LD, O'Brien C, and Harding SP: Retinal venous sheathing and the blood-retinal barrier in multiple sclerosis. Arch Ophthalmol. 1996 Jan;114(1):34-9.

LeVine SM: Iron deposits in multiple sclerosis and Alzheimer's disease brains. Brain Res. 1997 Jun;760(1-2):298-303.

Juurlink BH: The multiple sclerosis lesion: initiated by a localized hypoperfusion in a central nervous system where mechanisms allowing leukocyte infiltration are readily upregulated? Med Hypotheses. 1998 Oct;51(4):299-303.

Engell T, Sellebjerg F, and Jensen C: Changes in the retinal veins in acute optic neuritis. Acta Neurol Scand. 1999 Aug;100(2):81-3.

Tan IL, van Schijndel RA, Pouwels PJ, van Walderveen MA, Reichenbach JR, Manoliu RA, and Barkhof F: MR venography of multiple sclerosis. AJNR Am J Neuroradiol. 2000 Jun-Jul ;21(6):1039-42.

Bakshi R, Benedict RH, Bermel RA, Caruthers SD, Puli SR, Tjoa CW, Fabiano AJ, and Jacobs L: T2 hypointensity in the deep gray matter of patients with multiple sclerosis: a quantitative magnetic resonance imaging study. Arch Neurol. 2002 Jan;59(1):62-8.

Minagar A, and Alexander JS: Blood-brain barrier disruption in multiple sclerosis. Mult Scler. 2003 Dec;9(6):540-9.

F: Multiple Sclerosis: The Image and its Message. The Meaning of the Classic Lesion Forms. ms-info.net. 04.05.2004.

Law M, Saindane AM, Ge Y, Babb JS, Johnson G, Mannon LJ, Herbert J, and Grossman RI: Microvascular abnormality in relapsing-remitting multiple sclerosis: perfusion MR imaging findings in normal-appearing white matter. Radiology. 2004 Jun;231(3):645-52.

Schelling F. Damaging venous reflux into the skull or spine: relevance to multiple sclerosis. Med Hypotheses. 1986 Oct;21(2):141-8.

Marrie RA, Rudick R, Horwitz R, Cutter G, Tyry T, Campagnolo D, and Vollmer T: Vascular comorbidity is associated with more rapid disability progression in multiple sclerosis. Neurology. 2010 Mar;74(13):1041-7.

Williams BJ, Skinner HJ, and Maria BL: Increased intracranial pressure in a case of pediatric multiple sclerosis. J Child Neurol. 2008 Jun;23(6):699-702.

Inglese M, Adhya S, Johnson G, Babb JS, Miles L, Jaggi H, Herbert J, and Grossman RI: Perfusion magnetic resonance imaging correlates of neuropsychological impairment in multiple sclerosis. J Cereb Blood Flow Metab. 2008 Jan;28(1):164-71. Epub 2007 May 02.

Inglese M, Park SJ, Johnson G, Babb JS, Miles L, Jaggi H, Herbert J, and Grossman RI: Deep gray matter perfusion in multiple sclerosis: dynamic susceptibility contrast perfusion magnetic resonance imaging at 3 T. Arch Neurol. 2007 Feb;64(2):196-202.

Simon J: Ischemia and multiple sclerosis: perfusion MR imaging provides insight into an underexplored pathophysiology. AJNR Am J Neuroradiol. 2005 Jun-Jul ;26(6):1306-8

Ge Y, Law M, Johnson G, Herbert J, Babb JS, Mannon LJ, and Grossman RI: Dynamic susceptibility contrast perfusion MR imaging of multiple sclerosis lesions: characterizing hemodynamic impairment and inflammatory activity. AJNR Am J Neuroradiol. 2005

Wuerfel J, Bellmann-Strobl J, Brunecker P, Aktas O, McFarland H, Villringer A, and Zipp F: Changes in cerebral perfusion precede plaque formation in multiple sclerosis: a longitudinal perfusion MRI study. Brain. 2004 Jan;127(Pt 1):111-9. Epub 2003 21

Newman NJ, Selzer KA, and Bell RA: Association of multiple sclerosis and intracranial hypertension. J Neuroophthalmol. 1994 Dec;14(4):189-92.

Swank RL, Roth JG, and Woody DC: Cerebral blood flow and red cell delivery in normal subjects and in multiple sclerosis. Neurol Res. 1983 ;5(1):37-59.

Wiehl M: Venöse Insuffizienz im Gehirn bei MS entdeckt. Ärzte Zeitung für Neurologen/Psychiater, 23. Juni 2010

Ferlini A, Bovolenta M, Neri M, Gualandi F, Balboni A, Yuryev A, Salvi F, Gemmati D, Liboni A, and Zamboni P: Custom CGH array profiling of copy number variations (CNVs) on chromosome 6p21.32 (HLA locus) in patients with venous malformations associated with multiple sclerosis. BMC Med Genet. 2010 Apr;11(1):64. Epub 2010 Apr 28.

Zamboni P: Chronic cerebrospinal venous insufficiency. Int Angiol. 2010 Apr;29(2):91-2.

Embry AF: Integrating CCSVI and CNS autoimmunity in a disease model for MS. Int Angiol. 2010 Apr;29(2):93-4.

Lee AB, Laredo J, and Neville R: Embryological background of truncular venous malformation in the extracranial venous pathways as the cause of chronic cerebro spinal venous insufficiency. Int Angiol. 2010 Apr;29(2):95-108. PMID 20351665.

Simka M, Kostecki J, Zaniewski M, Majewski E, and Hartel M: Extracranial Doppler sonographic criteria of chronic cerebrospinal venous insufficiency in the patients with multiple sclerosis. Int Angiol. 2010 Apr;29(2):109-14.

Al-Omari MH, and Rousan LA: Internal jugular vein morphology and hemodynamics in patients with multiple sclerosis. Int Angiol. 2010 Apr;29(2):115-20.

Menegatti E, Genova V, Tessari M, Malagoni AM, Bartolomei I, Zuolo M, Galeotti R, Salvi F, and Zamboni P: The reproducibility of colour Doppler in chronic cerebrospinal venous insufficiency associated with multiple sclerosis. Int Angiol. 2010 Apr;29(2):121-6.

Hojnacki D, Zamboni P, Lopez-Soriano A, Galleotti R, Menegatti E, Weinstock-Guttman B, Schirda C, Magnano C, Malagoni AM, Kennedy C, Bartolomei I, Salvi F, and Zivadinov R: Use of neck magnetic resonance venography, Doppler sonography and selective venography for diagnosis of chronic cerebrospinal venous insufficiency: a pilot study in multiple sclerosis patients and healthy controls. Int Angiol. 2010 Apr;29(2):127-39.

Zamboni P, Menegatti E, Weinstock-Guttman B, Schirda C, Cox JL, Malagoni AM, Hojnacki D, Kennedy C, Carl E, Dwyer MG, Bergsland N, Galeotti R, Hussein S, Bartolomei I, Salvi F, Ramanathan M, and Zivadinov R: CSF dynamics and brain volume in multiple sclerosis are associated with extracranial venous flow anomalies: a pilot study. Int Angiol. 2010 Apr;29(2):140-8.

Haacke EM, Garbern J, Miao Y, Habib C, and Liu M: Iron stores and cerebral veins in MS studied by susceptibility weighted imaging. Int Angiol. 2010 Apr;29(2):149-57.

Zivadinov R, Schirda C, Dwyer MG, Haacke ME, Weinstock-Guttman B, Menegatti E, Heininen-Brown M, Magnano C, Malagoni AM, Wack DS, Hojnacki D, Kennedy C, Carl E, Bergsland N, Hussein S, Poloni G, Bartolomei I, Salvi F, and Zamboni P: Chronic cerebrospinal venous insufficiency and iron deposition on susceptibility-weighted imaging in patients with multiple sclerosis: a pilot case-control study. Int Angiol. 2010 Apr;29(2):158-75.

Malagoni AM, Galeotti R, Menegatti E, Manfredini F, Basaglia N, Salvi F, and Zamboni P: Is chronic fatigue the symptom of venous insufficiency associated with multiple sclerosis? A longitudinal pilot study. Int Angiol. 2010 Apr;29(2):176-82.

Bartolomei I, Salvi F, Galeotti R, Salviato E, Alcanterini M, Menegatti E, Mascalchi M, and Zamboni P: Hemodynamic patterns of chronic cerebrospinal venous insufficiency in multiple sclerosis. Correlation with symptoms at onset and clinical course. Int Angiol. 2010 Apr;29(2):183-8.

Plasmati R, Pastorelli F, Fini N, Salvi F, Galeotti R, and Zamboni P: Chronic cerebro-spinal venous insufficiency: report of transcranial magnetic stimulation follow-up study in a patient with multiple sclerosis. Int Angiol. 2010 Apr;29(2):189-92.

Simka M, and Zaniewski M: Reinterpreting the magnetic resonance signs of hemodynamic impairment in the brains of multiple sclerosis patients from the perspective of a recent discovery of outflow block in the extracranial veins. J Neurosci Res. 2010 Feb.

Qiu W, Raven S, Wu JS, Carroll WM, Mastaglia FL, and Kermode AG: Wedge-shaped medullary lesions in multiple sclerosis. J Neurol Sci. 2010 Jan.

Lee BB, Bergan J, Gloviczki P, Laredo J, Loose DA, Mattassi R, Parsi K, Villavicencio JL, and Zamboni P: Diagnosis and treatment of venous malformations Consensus Document of the International Union of Phlebology (IUP)-2009. Int Angiol. 2009 Dec;28(6):434-51. Montecarlo September 4th 2009

Zamboni P, Menegatti E, Weinstock-Guttman B, Schirda C, Cox JL, Malagoni AM, Hojanacki D, Kennedy C, Carl E, Dwyer MG, Bergsland N, Galeotti R, Hussein S, Bartolomei I, Salvi F, and Zivadinov R: The severity of chronic cerebrospinal venous insufficiency in patients with multiple sclerosis is related to altered cerebrospinal fluid dynamics. Funct Neurol. 2009 Jul-Sep ;24(3):133-8.

Zamboni P, Galeotti R, Menegatti E, Malagoni AM, Gianesini S, Bartolomei I, Mascoli F, and Salvi F: A prospective open-label study of endovascular treatment of chronic cerebrospinal venous insufficiency. J Vasc Surg. 2009 Dec;50(6):1348-58.e1-3.

Zamboni P, Menegatti E, Weinstock-Guttman B, Schirda C, Cox JL, Malagoni AM, Hojanacki D, Kennedy C, Carl E, Dwyer MG, Bergsland N, Galeotti R, Hussein S, Bartolomei I, Salvi F, and Zivadinov R: The severity of chronic cerebrospinal venous insufficiency in patients with multiple sclerosis is related to altered cerebrospinal fluid dynamics. Funct Neurol. 2009 Jul-Sep ;24(3):133-8.

Pirko I, and Zivadinov R: Transcranial sonography of deep gray nuclei: a new outcome measure in multiple sclerosis? Neurology. 2009 Sep;73(13):1006-7. Epub 2009 Aug 26.

Tallantyre EC, Morgan PS, Dixon JE, Al-Radaideh A, Brookes MJ, Evangelou N, and Morris PG: A comparison of 3T and 7T in the detection of small parenchymal veins within MS lesions. Invest Radiol. 2009 Sep;44(9):491-4.

Khalil M, Enzinger C, Langkammer C, Tscherner M, Wallner-Blazek M, Jehna M, Ropele S, Fuchs S, and Fazekas F: Quantitative assessment of brain iron by R(2)* relaxometry in patients with clinically isolated syndrome and relapsing-remitting multiple sclerosis. Mult Scler. 2009 Sep;15(9):1048-54. Epub 2009 Jun 25.

Walter U, Wagner S, Horowski S, Benecke R, and Zettl UK: Transcranial brain sonography findings predict disease progression in multiple sclerosis. Neurology. 2009 Sep;73(13):1010-7. Epub 2009 Aug 5.

Singh AV, and Zamboni P: Anomalous venous blood flow and iron deposition in multiple sclerosis. J Cereb Blood Flow Metab. 2009 Dec;29(12):1867-78. Epub 2009 Sep 02.

Zamboni P, Consorti G, Galeotti R, Gianesini S, Menegatti E, Tacconi G, and Carinci F: Venous collateral circulation of the extracranial cerebrospinal outflow routes. Curr Neurovasc Res. 2009 Aug;6(3):204-12. Epub 2009 Aug 1.

Zamboni P, Galeotti R, Menegatti E, Malagoni AM, Mascoli F, Dall'Ara S, Bartolomei I, and Salvi F: Rationale and preliminary results of endovascular treatment of multiple sclerosis, the liberation procedure. 2009, in 1978–2009 -31 years- Vascular and Endovascular Controversies Update 31st International Symposium – CX Charing Cross, pp. 71–79.

Simka M: Blood brain barrier compromise with endothelial inflammation may lead to autoimmune loss of myelin during multiple sclerosis. Curr Neurovasc Res. 2009 May;6(2):132-9.

Ge Y, Zohrabian VM, Osa EO, Xu J, Jaggi H, Herbert J, Haacke EM, and Grossman RI: Diminished visibility of cerebral venous vasculature in multiple sclerosis by susceptibility-weighted imaging at 3.0 Tesla. J Magn Reson Imaging. 2009 May;29(5):1190-4.

Franceschi C: The unsolved puzzle of multiple sclerosis and venous function. J Neurol Neurosurg Psychiatry. 2009 Apr;80(4):358.

Zamboni P, Galeotti R, Menegatti E, Malagoni AM, Tacconi G, Dall'Ara S, Bartolomei I, and Salvi F: Chronic cerebrospinal venous insufficiency in patients with multiple sclerosis. J Neurol Neurosurg Psychiatry. 2009 Apr;80(4):392-9. Epub 2008 Dec 5.

Haacke EM, Makki M, Ge Y, Maheshwari M, Sehgal V, Hu J, Selvan M, Wu Z, Latif Z, Xuan Y, Khan O, Garbern J, and Grossman RI: Characterizing iron deposition in multiple sclerosis lesions using susceptibility weighted imaging. J Magn Reson Imaging. 2009 Mar;29(3):537-44.

Zamboni P, Menegatti E, Galeotti R, Malagoni AM, Tacconi G, Dall'Ara S, Bartolomei I, and Salvi F: The value of cerebral Doppler venous haemodynamics in the assessment of multiple sclerosis. J Neurol Sci. 2009 Jul;282(1-2):21-7.

Mittal S, Wu Z, Neelavalli J, and Haacke EM: Susceptibility-weighted imaging: technical aspects and clinical applications, part 2. AJNR Am J Neuroradiol. 2009 Feb;30(2):232-52. Epub 2009 Jan 8. Type: Review.

Haacke EM, Mittal S, Wu Z, Neelavalli J, and Cheng YC: Susceptibility-weighted imaging: technical aspects and clinical applications, part 1. AJNR Am J Neuroradiol. 2009 Jan;30(1):19-30. Epub 2008 Nov 27.

Simka M, and Rybak Z: Hypothetical molecular mechanisms by which local iron overload facilitates the development of venous leg ulcers and multiple sclerosis lesions. Med Hypotheses. 2008 Aug;71(2):293-7. Epub 2008 Apr 8.

Talbert DG: Raised venous pressure as a factor in multiple sclerosis. Med Hypotheses. 2008 ;70(6):1112-7. Epub 2008 Feb 20.

Ge Y, Zohrabian VM, and Grossman RI: Seven-Tesla magnetic resonance imaging: new vision of microvascular abnormalities in multiple sclerosis. Arch Neurol. 2008 Jun;65(6):812-6.

Zuolo M: Chronic Cerebrospinal Venous Insufficiency in Patients with Multiple Sclerosis: An Experimental Study. Disseration 2007-2008, Supervisor: Zamboni P, University of Ferrara

Menegatti E, and Zamboni P: Doppler haemodynamics of cerebral venous return. Curr Neurovasc Res. 2008 Nov;5(4):260-5.

De Keyser J, Steen C, Mostert JP, and Koch MW: Hypoperfusion of the cerebral white matter in multiple sclerosis: possible mechanisms and pathophysiological significance. J Cereb Blood Flow Metab. 2008 Oct;28(10):1645-51. Epub 2008 Jul 02.

Zamboni P, Menegatti E, Bartolomei I, Galeotti R, Malagoni AM, Tacconi G, and Salvi F: Intracranial venous haemodynamics in multiple sclerosis. Curr Neurovasc Res. 2007 Nov;4(4):252-8

Zamboni P: The big idea: iron-dependent inflammation in venous disease and proposed parallels in multiple sclerosis. J R Soc Med. 2006 Nov;99(11):589-93.

Sclafani SJ (Commentary by Dake MD and Katzen BT): Chronic Cerebrospinal Venous Insufficiency: A new paradigm and therapy for multiple sclerosis. Encovascular Today. July 2010:41-6.

Habib CA, Zheng W, Haacke EM, Webb S, Nichol H: Visualizing Iron Deposition in Multiple Sclerosis Cadaver Brains. In: Siu KKW, publisher. 6TH International conferensce on medical applications of synchrotron radiatiion. Melbourne (Australia): AIP; 2010. p. 78-83.

Alexander JS, Zivadinov R, Maghzi AH, Ganta VC, Harris MK, and Minagar A: Multiple sclerosis and cerebral endothelial dysfunction: Mechanisms. Pathophysiology. 2010 Jul:.

Phillips LA: This Way In: CCSVI and Multiple Sclerosis. Neurology Now. Jul/Aug 2010;6(4):9-11.

Haacke EM, Tang J, Neelavalli J, and Cheng YC: Susceptibility mapping as a means to visualize veins and quantify oxygen saturation. J Magn Reson Imaging. 2010 Sep;32(3):663-76.

Chung CP, Lin YJ, Chao AC, Lin SJ, Chen YY, Wang YJ, and Hu HH: Jugular Venous Hemodynamic Changes with Aging. Ultrasound Med Biol. 2010 Aug:.


Och, lite annat ni kan läsa...:

Arhart RW: A possible haemodynamic mechanism for Amyotrophic Lateral Sclerosis. Med Hypotheses. 2010 Apr:.

Young NP, Weinshenker BG, Parisi JE, Scheithauer B, Giannini C, Roemer SF, Thomsen KM, Mandrekar JN, Erickson BJ, and Lucchinetti CF: Perivenous demyelination: association with clinically defined acute disseminated encephalomyelitis and comparison with pathologically confirmed multiple sclerosis. Brain. 2010 Feb;133(Pt 2):333-48. Epub 2010 Feb 3.

Chung CP, Chao AC, Hsu HY, Lin SJ, and Hu HH: Decreased jugular venous distensibility in migraine. Ultrasound Med Biol. 2010 Jan;36(1):11-6. Epub 2009 Nov 8.

Zamboni P, Lanzara S, Mascoli F, Caggiati A, and Liboni A: Inflammation in venous disease. Int Angiol. 2008 Oct;27(5):361-9








MRI av MS

http://www.youtube.com/watch?v=-DqZ1VLRa2g&feature=related

Zamboni m fl. om CCSVI m m...

http://www.youtube.com/watch?v=iKGGTfGeExA

http://www.youtube.com/watch?v=ABsmf4OjDfM&NR=1


http://www.youtube.com/watch?v=x9cY6H61PfU&feature=related
http://www.youtube.com/watch?v=5pxG7MHpN04&feature=related
http://www.youtube.com/watch?v=Bf0fsqouOlE&feature=related
http://www.youtube.com/watch?v=tRCgHYHvd9k&feature=related
http://www.youtube.com/watch?v=MZnDzMuZ2Eo&feature=related
http://www.youtube.com/watch?v=Wcsi-U6eKBM&feature=related
http://www.youtube.com/watch?v=hhRfz8bTOkQ&feature=related

om MS


Hur man undersöker CCSVI:

http://www.youtube.com/watch?v=yGFe-3h26Vs&feature=related


Det finns snart hur mycket "bevis" som helst på hur "the liberation treatment har förändrat livet för många. Du hittar dem på Youtube.

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23.01 | 23:39

Tack Ewa

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23.01 | 23:38

Tack själv!

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23.01 | 23:38

Jag har sett något avsnitt på internet. Nej, mig veterligen är L H inte intresserad av CCSVI.

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18.01 | 17:46

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